Insulin Sensitivity

Insulin Sensitivity and Gut Health—A Dynamic Duo

Do you want your skin to look smooth and youthful for as long as possible?

Do you want your brain to be sharp?

What about losing weight and maintaining a slender, sleek body?

These are just some of the reasons to care about keeping your insulin and blood sugar levels balanced—even if you don’t have prediabetes or diabetes. Yet, when many people hear about insulin sensitivity they think it’s only relevant to diabetics.

That couldn’t be more wrong. 

There are good reasons for everyone to care about how their body is handling insulin. And surprisingly, it’s your gut that plays a major role in keeping this blood-sugar-balancing hormone in control. 

If your gut is unhealthy, your body won’t handle insulin well, which means your blood sugar will get out of whack. 

 

What Is Insulin Sensitivity?

Insulin is a hormone that’s made when our blood sugar (glucose) levels rise. It pushes extra glucose into the cells of our muscles and liver, where it’s stored as glycogen. But when our muscles or liver run out of closet space to store the glucose, the excess is converted into fat and stored in our fat reserves. 

When muscles and the liver run out of glycogen they should be able to tap into fat stores to replenish themselves, causing weight loss. 

However, if insulin is present in excess amounts, it blocks your body from tapping into those reserves.

What causes high insulin levels? Usually the culprit is high blood glucose in the form of glucose spikes that often happen even in people without diabetes.  

Insulin sensitivity refers to the body’s ability to respond to the blood-sugar-lowering signals that insulin is broadcasting. If the body can’t respond to those signals, it starts making more and more insulin to try to “hear” what insulin is saying. Kind of like talking louder when someone can’t hear you. Reduced insulin sensitivity is known as insulin resistance. In other words, your body isn’t as sensitive to insulin anymore so it needs to make more and more.  

 

Why You Should Care About Insulin Sensitivity

Poor insulin sensitivity and glucose spikes are to blame for a number of health problems, not just diabetes. For example, they’re linked to:

  • Accelerated skin aging and more rapid development of wrinkles
  • Acne and other inflammatory skin conditions
  • Adrenal stress
  • Arthritis and other inflammatory diseases
  • Cravings
  • Depressive episodes
  • Digestive symptoms like leaky gut, heartburn, acid reflux
  • Fatigue/chronic fatigue
  • Heart disease
  • Increased cancer risk
  • Increased risk of Alzheimer’s disease and dementia
  • Infertility and polycystic ovary syndrome (PCOS)
  • Memory problems
  • Migraines
  • Non-alcoholic fatty liver disease (NAFLD)
  • Poor sleep (waking during the night)
  • Suppressed immune response
  • Type 2 diabetes
  • Worsening of hormonal hot flashes and night sweats

 

How The Gut Controls Insulin Sensitivity

Problems in the gut lead to problems with blood sugar and the way your body uses insulin. Usually people don’t connect the gut with insulin problems, but there is a HUGE connection between the two.

Here’s the deal: The gut affects insulin sensitivity in five ways. Some of these might sound kind of technical, but bear with me for a moment as I’ll explain them all in a minute.

  1. Leaky gut
  2. Endotoxemia 
  3. Production of short-chain fatty acids like butyrate
  4. Alterations in bile acid metabolism
  5. Effects on the secretion of gut hormones

The common denominator in all five of these factors is an imbalance in the gut microbiota. The gut microbiota are the little organisms that live in your intestines, both good and bad bacteria, viruses, and fungi. Scientists call an imbalance in the gut microbiota dysbiosis. Dysbiosis is common in diabetes, suggesting the gut microbiota and blood sugar problems are connected. In diabetes, levels of beneficial bacteria are decreased, whereas many harmful bacteria are increased. Small intestinal bacterial overgrowth is also common in diabetes.  

 

Leaky Gut

Gut microbiota dysbiosis can lead to leaky gut, otherwise known as increased intestinal permeability. Leaky gut is the name for what happens when a person’s intestinal lining is weakened. This weakened lining allows toxins and bacteria to slip through into the bloodstream, causing problems throughout the body. Leaky gut creates inflammation and reduces insulin sensitivity. There’s also a link between leaky gut and diabetes.  

 

Low-Grade Endotoxemia 

Bacteria in the body produce a type of toxin known as an endotoxin, primarily a bad guy known as LPS. It’s a component of bacterial cell walls found mostly in gram-negative bacteria. When LPS escapes the colon during leaky gut and becomes a fugitive on the run throughout the body, it triggers an inflammatory response known as endotoxemia. 

LPS also does a number on the way your body uses insulin. LPS triggers an inflammatory cascade in every type of tissue it comes into contact with in the body. In insulin receptors, this inflammation leads to reduced sensitivity to insulin—or—insulin resistance. 

Endotoxemia and leaky gut go hand in hand. Since the intestinal lining is weaker, it allows these toxins to escape into the bloodstream, causing problems that at first glance don’t seem as if they’re linked to the gut. 

 

Butyrate and Short-Chain Fatty Acids

Short-chain fatty acids like butyrate are important for gut health and insulin sensitivity. Bacteria in the gut, especially those that belong to the phylum Firmicutes, make butyrate. If your gut isn’t making enough butyrate it spells trouble for the way your body uses insulin. 

In studies of obese mice, butyrate supplementation increased insulin sensitivity and improved weight loss. Fasting blood glucose, fasting insulin, and insulin tolerance remained normal in mice given butyrate.

In humans, if there aren’t enough butyrate-producing bacteria, it boosts the risk of metabolic disorders like diabetes. 

Butyrate repairs the intestinal lining and reduces inflammation, helping to get rid of leaky gut, which in turn promotes healthy blood sugar levels.  

 

Bile Acid Metabolism

Another way in which the gut controls insulin sensitivity is by regulating the way the body produces bile acids, which stimulate insulin secretion. People with leaky gut don’t recirculate bile acids efficiently. So they wind up with bile acid deficiency over time, which leads to inefficient detoxification as well as changes in how your body regulates fat and carb digestion.

 

Secretion of Gut Hormones

A healthy gut equals healthy amounts of gut-derived metabolic hormones called glucagon-like peptides (GLP-1), which are linked to blood sugar balance. GLP-1 boosts insulin levels when there’s glucose in the blood, helping to push glucose into your cells to improve blood sugar levels.  

GLP-1 also keeps you feeling full and satisfied after eating so that you can stay away from desserts and other unhealthy foods.  

 

How To Know If You Have Blood Sugar Issues

One of the best ways to monitor your insulin and blood sugar levels is to work with a functional medicine provider, who will order lab tests. The lab tests to measure insulin sensitivity and blood glucose include:

  • Fasting glucose, optimal range 70 to 85
  • Fasting insulin, optimal below 5
  • Fasting uric acid, optimal less than 5.5
  • HBA1c (a measure of blood sugar control over time), optimal range 4.8 to 5.2

Also important: Finding out if your gut is healthy by using a stool test. I like the BiomeFX panel.

The second way to see how your body is coping with blood sugar is to monitor glucose spikes. Everybody has glucose spikes to a certain extent. But when insulin sensitivity is low, blood sugar spikes are often too high since insulin is unable to control your blood glucose. 

The best way to monitor glucose spikes is by using a glucose monitor for two to four weeks. Monitor readings should be 70 to 120 the majority of the time, but even more ideal is 70 to 100. Lots of people spike above 140, even if they’re not diabetic, but most of us shouldn’t be going over 120 most of the time.  

 

What To Do About Glucose Spikes and Reduce Insulin Sensitivity

Eat Foods That Support Butyrate and Probiotic Bacteria

The main goals of balancing blood sugar and insulin are to raise butyrate levels and to get rid of any gut microbiota imbalances. 

From a dietary perspective, there are certain foods you can eat to increase butyrate levels.

Butyrate foods include:

  • Apples
  • Leeks
  • Onions

To support a healthy gut microbiota, eating high-fiber foods rich in prebiotics is a good first step. These types of foods can also help butyrate-producing bacteria flourish. Research has shown that eating fermentable fiber was linked to an increase in the beneficial bacteria Bifidobacteria. This type of fiber also normalized LPS and improved glucose tolerance and insulin secretion, while reducing inflammation. 

Prebiotic foods include:

  • Apples
  • Beans
  • Bran
  • Chicory root
  • Garlic
  • Jerusalem artichoke
  • Oat bran 
  • Onions
  • Psyllium husk
  • Tomatoes

It’s also a good idea to limit sugar and saturated fat, since these can cause butyrate levels to tank. 

 

Butyrate Supplements and Other Solutions

Another way to increase butyrate levels is through using certain dietary supplements. In animal studies, giving mice butyrate supplements blocked the development of insulin resistance caused by eating a high-fat diet.

Probiotics containing Bacillus bacteria endospores such as MegaSporeBiotic can increase butyrate-producing bacteria in the gut. 

Certain supplements can also boost butyrate production directly. These include:

I have found that it’s possible to boost butyrate by 140% in four weeks using a combo of MegaSporeBiotic and MegaPre—which only feed selectively the keystone bacteria species, not the bad guys—along with MegaMucosa to heal and repair leaky gut with essential nutrients as building blocks.  

 

Balancing Blood Sugar By Improving Gut Health

I have seen so many patients experience an improvement in their health after addressing gut issues, restoring butyrate levels, and balancing insulin and blood sugar levels. They’ll often have improved energy, clearer skin, better sleep, less hot flashes, and many of their other health complaints go away. 

You’re going to have the greatest success working with a functional medicine provider who can tackle all the bases.  That’s why I invite you to reach out to me for a free 15-minute call to find out the best course of action for you. 

If after the call you come on board as a patient, I’ll order the right tests for you. Based on the results and your symptoms, I’ll start you on a protocol to balance blood sugar, improve your gut health, and help you look and feel your best. 


Hands over pregnant stomach in the shape of a heart

My Not-So-Glowing Pregnancy Truth: How I Wound Up With Gestational Diabetes (And What I’m Doing About It)

I’ve been really lucky to enjoy every moment of my pregnancy so far. I feel good. I’ll even say I’m “glowing”! I’m so excited to become a mom and really enjoying the journey.

But my pregnancy joy hit a bump in the road after my 26-week appointment.

If you’re a mama-to-be or already have kiddos, you know what happens at the 26-week appointment: testing for gestational diabetes.

My OB and I decided that instead of traditional testing (more on that later) I could test my blood sugar at home.

I’ve never had fasting glucose above 90, so gestational diabetes wasn’t even on my radar. I was stunned when my fasting glucose was 114!

After testing my blood sugar a couple more times, I called my OB. She confirmed what I already knew: I met the clinical requirements for a gestational diabetes diagnosis!

So much for “glowing”...

But, I believe EVERYTHING happens for a reason…

Why I’m Grateful I Have Gestational Diabetes

I know it sounds a little out there… but at then end of the day I’m actually grateful for this diagnosis.

I hope I can remove some of the stigma around gestational diabetes.

A GD diagnosis doesn’t mean you’re doing anything wrong. You can still have a happy, healthy pregnancy.

But I also think it’s high time we take a hard look at the usual suggestions for moms with GD. As I’ll share in this post, what most doctors recommend isn’t the only option.

I’m going to share:

  • What gestational diabetes is
  • Testing for GD (and the alternative to traditional testing)
  • Who gets gestational diabetes and why (you’ll be surprised by this one)
  • What you can do to manage it (and exactly what I’m doing)

What Is Gestational Diabetes?

Gestational diabetes is basically just high blood sugar that develops (or is first noticed) during pregnancy.

Even women who have 100% normal blood glucose readings before pregnancy can develop gestational diabetes.

Why?

During pregnancy, the placenta, which connects your baby to your blood supply for nutrients and clearing waste, produces high levels of various other hormones. Almost all of these hormones impair the action of insulin in your cells, raising your blood sugar.

Modest elevation of blood sugar after meals is normal during pregnancy. The bigger your baby grows, the more of these insulin-blocking hormones your placenta produces - which is why gestational diabetes is more likely to present in 2nd and 3rd trimester.

Gestational diabetes is diagnosed when fasting glucose is above 100 - but it’s ideal to have it stay at 90 or below. Post-prandial (after meals) glucose above 130 at any time also suggests GD.

Sometime gestational diabetes is called “carbohydrate intolerance” because it’s high levels of carbohydrates that trigger the high blood sugar.

Why Gestational Diabetes Is A Problem

While slightly elevated blood sugar is a normal thing in pregnancy, gestational diabetes is NOT something you should ignore.

If it’s not addressed GD can cause serious issues for mom and baby:

  • Baby can grow too large (think 9 pounds and up)
  • Increased risk of preterm birth
  • Increased risk of respiratory distress syndrome for baby
  • Increased risk of preeclampsia for mom (high blood pressure)
  • Increased risk of Type 2 Diabetes down the road for mom AND baby

All of these risks can be mitigated if gestational diabetes is discovered and managed - that’s why all women should be screened for gestational diabetes.

Most cases of gestational diabetes can be managed with diet and exercise alone - but some women do need insulin, as well.

How Do I Know If I Have Gestational Diabetes?

EVERY woman should be screened for gestational diabetes. But we don’t all have to be tested the same way.

The most common test for gestational diabetes is called 3-hour glucose tolerance testing. It works like this: you go to the doctor fasting and have your blood sugar tested. Next, you drink a solution that contains 75 grams of fructose. Then, you’ll have your blood sugar tested every hour for 3 hours after.

My main issue with 3-hour glucose tolerance testing (besides drinking that nasty solution) is this: Who actually consumes 75 grams of sugar in one sitting?  

I certainly don’t!

Unless you’re guzzling soda or supersized slushies, you’re probably not taking in this much sugar at once, either. It’s the equivalent of 2 large pancakes with syrup - but even if you DID eat the pancakes, you’d have the fat, fiber, and protein in the rest of the meal slowing your absorption of the sugar into your bloodstream.

Because I don’t eat much refined sugar, I didn’t think this type of testing was ideal for me. I asked my OB if I could test my own blood sugar (fasting and post-meal) at home with my glucometer instead and she agreed.

(Side note: my OB is awesome. Every woman deserves a pregnancy care team they trust. Don’t be afraid to try out a couple different doctors until you find a team that listens, makes you feel heard and understand, and is responsive to YOUR wants. That doesn’t mean they’ll always say yes to what you want - but they should be willing to consider your requests.)

My Test Results

The next day I ran my fasting glucose…..yikes…106?

Pre-pregnancy, I’d never had fasting blood sugar above 90!

Post-meal, I tested at 127 - then later it rose to 141. I knew that wasn’t good.

The next day, my fasting was 114.

(Remember - GD is diagnosed when fasting glucose is above 100 and post-meal rises above 130).

The results were a shock to me - especially because I’d been following a lower-carb, Paleo/keto style diet. In pregnancy, I’d increased my carbs a little - think a gluten free waffle with almond butter, a teaspoon of honey in my tea, or a slice of gluten free bread once a day.

Pregnancy cravings are real - but it’s not like I was eating pints of ice cream or loaves of bread. How could I have gestational diabetes?

Risk Factors For Gestational Diabetes

Once I took a deep breath, I reminded myself of what I already knew:

Even women with totally normal fasting glucose and good general glucose control can wind up with gestational diabetes in pregnancy.

It wasn’t my diet, but my genetics that put me at increased risk for GD:

#1 I have Polycystic Ovarian Syndrome (PCOS) —this leaves me already more prone to insulin resistance

#2 I have a family history of Type 2 Diabetes - and my mom had gestational diabetes in her pregnancy

#3 I’m non-white. Scientists aren’t sure why, but non-white people have an increased risk of gestational diabetes

Being overweight is also a risk factor for gestational diabetes, but not one that I have personally.

Once I accepted that I had GD, I shifted to action mode: how was I going to manage this so I didn’t need insulin injections?

The Normal Treatment For Gestational Diabetes

The standard recommendations for managing GD is a diet high in complex carbs - about 175 grams per day.

Suggested sources of complex carbs are bananas, whole grains, fruit, rice, and oats.

You’ll also need to monitor your blood sugar 4-7 times per day with a glucometer at home.

Many women are even required to meet with a dietitian to help implement these changes (my insurance required this).

If these diet changes can’t manage your blood sugar, the next step is insulin injections.

As a functional medicine practitioner, these recommendations didn’t jibe with me.

What made more sense to me: a modified keto diet and closely monitoring my blood sugar (plus getting gentle exercise - like walking - every day).

My OB agreed that as long as I could keep my fasting glucose under 100 (preferably under 90) and my post-meal under 120, I could do what worked for me.

An Alternative Way To Manage Gestational Diabetes

A modified keto diet (aka low carb) makes sense for managing gestational diabetes because it is carbohydrates that cause the rise in blood sugar.

Eat less carbs and your blood sugar won’t rise as high. It’s pretty simple (and intuitive).

While I’d like to take credit for the idea of using a modified keto diet to manage gestational diabetes, it was actually Dr. Lois Jovanic. Dr. Jovanic is one the the foremost experts on diabetes in pregnancy and previous director and chief scientific officer of the Sansum Diabetes Research Center.

Here’s what she has to say about the standard recommendations:

“Honestly, 175 g of carbohydrate is stupid! Women should be going as low as it takes to keep their blood sugar regularly under 90 mg/dl (5 mmol/L). Women ask me, ‘Do I have to eat carbohydrates?’ and I say, ‘No you do not!’ If you do eat carbohydrates [with GD], you will have to have insulin. It is that simple.”

Nutritional ketosis is actually a natural state for pregnant women: pregnant women have higher circulating blood ketones than non-pregnant women.

So why is the standard recommendation to eat 175 grams of carbs per day?

It’s because of a misguided fear of diabetic ketoacidosis in pregnant women. One sign of diabetic ketoacidosis is high levels of ketones in the urine - but that doesn’t mean that ketosis and ketoacidosis are the same thing.

Some experts even suggest that having circulating ketone is not only normal and safe, but supportive to optimal fetal neurologic and brain development.

What To Eat When You Have Gestational Diabetes

No matter what diet you’re eating, the MOST important thing is to regularly test your blood sugar levels to ensure they stay in the normal ranges. Both too high and too low are dangerous for growing baby - so test regularly.

Testing 4 -7 times a day is a good place to start. Test when you wake up (fasting) and then after each meal. If you blood sugar rises too high after a meal, that’s a sign you ate too many carbohydrates at that meal.

Secondly, it’s important to eat adequate calories and to not go long periods of time between meals. If you’re not eating enough or going too long between meals, you’re more likely to have problems managing your glucose levels.

Dr. Jovanic also recommend avoiding what she calls “naked carbs” or eating carbohydrate-rich foods all by themselves. Instead, pair carbs with fat and protein to slow absorption. (I.e. a handful of crackers by itself vs. crackers with nut butter).

Getting exercise every day also helps manage blood sugar levels.

What I’m Eating Now

Here’s a peek into what a day of eating looks like for me:

Breakfast: 2 eggs with a sprinkle of shredded pasture raised cheese, cooked in pasture raised butter. Topped with a small avocado and a handful of sliced cherry tomatoes. Rasa herbal Koffee with a splash of grass-fed whole cream and a scoop of collagen.

Lunch: steamed veggies (broccoli, cauliflower, zucchini) with tahini sauce and poached salmon.

Snack: chicken liver pate on celery sticks

Dinner: Homemade Tom Kha soup with veggies, chicken, coconut milk, lime juice, coconut aminos, fish sauce, and green curry paste –yum!!

One last important change I made: adding in late night protein, right before bed.

When I first switched to low carb meals, my post-meal glucose dropped right into line. But my fasting glucose in the morning was still too high. Why? It was because of something called the “Dawn Phenomenon.”

The Dawn Phenomenon occurs when your fast overnight (for me, it was 12+ hours between my dinner and breakfast). The extended fast would kick my body into gluconeogenesis, causing my morning fasting glucose to spike (usually between 99 and 106).

Increasing my evening protein (instead of half a chicken breast, I’d eat a whole one) and adding a tablespoon of psyllium husk to help slow glycemic uptake both did the trick: as soon as I made those changes, my fasting glucose dropped below 90 and stayed there.

My Gestational Diabetes Journey (And My Goal In Sharing This)

For now, eating a modified keto diet, exercising, and testing my glucose levels 4-7x times a day is working to manage my gestational diabetes.

My OB and I are both verrrry happy with my results and that I don’t need to use insulin shots. (And I’m sure baby boy is too!)

As my pregnancy progresses, I might need to switch things up: adding a bit more carbs in or dropping my levels down. Regular glucose testing will help me know what to do.

My goal in sharing this information is to help remove the stigma around gestational diabetes and bring light to an alternative way of managing GD that might work better for you.

But keep baby’s safety first in mind: if you have GD, you should talk with your doctor before making any changes to your treatment plan.

Have a doc who’s unwilling to even consider an alternative to the standard recommendations? It might be time to find a doctor who is willing to work with you.

Hang in there, mama! I know how scary a gestational diabetes diagnosis can be - but I also know you can manage it and keep on glowing.

If this resonates with you, I’d be honored to have you book a 20-minute consult with my team. These consults are totally free and a chance for us to share how we are trained to help you!

→ Learn more and book a free consult with my team here.